OUR APPROACH

Our Approach 

 

Bacainn approaches inflammation differently in gastrointestinal and respiratory diseases 

 

In exploring novel approaches for ulcerative colitis, Bacainn looked beyond the role of T Cells in inflammation to see the potential of blocking neutrophil accumulation and activity in the colon.   

Our neutrophil-directed therapeutic for ulcerative colitis is designed to be gut-restricted and restore a normal balance of migration and activation of these “first responder” immune cells. The resulting modulation of neutrophils reduces their potential to cause intestinal tissue damage and the release of further proinflammatory signals 

 

For respiratory inflammation, a breakthrough discovery of proprietary compounds that simultaneously block NLRP1 and NLRP3 inflammasomes and reduce levels of proinflammatory mediators such as IL1β offer exciting new potential for the treatment of inflammatory respiratory diseases 

Bacainn Therapeutics

Ulcerative Colitis

Ulcerative colitis (UC) is a chronic, idiopathic inflammatory disease that targets the colon. It is characterized by relapsing and remitting mucosal inflammation. UC inflammation is known to be associated with the presence of high levels of neutrophils and neutrophil biomarkers (e.g., calprotectin). The incidence and prevalence of UC has been increasing worldwide with a prevalence in the US estimated at >200 cases per 100,000 persons per year. Moderate to severe UC can be extremely debilitating to the affected patient, with a major impact on quality of life, overall health and predisposition to gastrointestinal cancer. Pharmacological treatments for moderate to severe UC include anti-inflammatory agents, immunosuppressants (e.g., azathioprine and 6-mercaptopurine), corticosteroids and immunomodulating biologics (e.g., Humira®, Entyvio®).. Although these treatments can be effective at inducing remission in patients, typical side-effects are significant, including increased risk of infection and malignancies, and tolerability. In addition, corticosteroids cannot be used long term, and newer biologics are only effective in about 20% of patients. Therefore, there is an unmet need for safer, more effective treatments.

Orally dosed BT051 is specifically targeted to modulate both neutrophil migration to the colonic lumen and their activation once there. The drug lacks general immunosuppressive activity and has been shown to have very low systemic exposure and a good safety profile in preclinical studies.

Respiratory inflammation can occur as a result of viral, bacterial or fungal infection, chemical exposure or inhalation of foreign particulates such as silica, allergens and smoke. The beneficial aspects of inflammation help to clear infection or repair the effects of these insults. If the inflammation becomes chronic or uncontrolled, patients can suffer irreversible lung damage, and in extreme cases, fluid and immune cell buildup leading to hypoxia and death. The latter often occurs in patients infected with respiratory viruses such as seasonal as well as pandemic influenza such as the current SARS-CoV-2.

Bacainn’s anti-inflammatory molecules have demonstrated benefit in preclinical models of pandemic influenza. Our treatments both prolong survival in these models and reduce overt immune cell activity late in disease. We intend to advance these molecules to pre-clinical safety studies to enable their testing in humans.